ملخص رسالة عمار عبد الحسين

Abstract

In this work two series of new azoaldonitrones have been synthesized. At first,      azoaldehydes  [A1-A10] were   prepared   via  coupling reactions between the

diazonium salts of the primary aromatic amines (2-amino-5-mercapto-1,3,4-thiadiazole, 3-aminopyridine, 4-methoxyaniline, 2,4-dichloroaniline, 4-chloroaniline, 2-chloroaniline, 3-bromoaniline, 3-nitroaniline, 4-nitroaniline and benzidine, respectively) and alkaline solution of 2-hydroxybenzaldehyde as coupling reagent. Next, the resulting azoaldehydes [A1-A10] were introduced in acid-catalyzed condensation reactions with phenylhydroxylamine in absolute ethanol to obtain ten new azoaldonitrones [N1-N10] respectively. Later, treatment of azoaldehydes [A1-A5] with benzylhydroxylamine under the same conditions afforded five new aldonitrones [A11-A15] respectively. The structures of the synthesized azoaldonitrones were confirmed by (C.H.N.S) elementary analysis and the spectroscopic methods including FT-IR and 1H NMR. The synthesized azo aldonitrones [N1-N15] were tested for their antibacterial activity against two pathogenic strains of bacteria Staphylococcus aureous (Gram-positive) and Escherichia coli (Gram-negative). The results revealed that azoaldonitrones [N1] and [N11] which are containing thiadiazole moiety showed higher activity against both strains of bacteria, while compound [N6] appeared higher activity only against Gram positive bacteria. Moreover, most of the prepared azoaldonitrone compounds showed medium activity against Gram positive bacteria and weak activity against Gram negative bacteria

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