ملخص رسالة تغريد عبد نجم

abstract

The present study was included sixty patients with type II diabetes

mellitus(T2DM) with mean duration of 10 ± 7 years (20male and 40

female) and thirty apparently healthy individuals with mean age of 55 ±

5.7 attending al Hussain medical city in Karbala province, from May to

August 2013. The patients were non-smoker, don’t have any history of

chronic disease and using Glucophage and daonil as drug.

The results was shown significantly decrease at P ≤ 0.05 in the percent of

phagocytosis in T2DM patients 62% ± 0.06 , 69% ± 0.44 group1 &

group2 respectively as compared with control whereas the percent was

82% ± 0.24 .

Extracellular and intracellular free radicals level such as superoxide

dismutase (SOD3 & SOD1), nitric oxide (NO) and malondialdehyde

(MDA) was determined and the results was shown elevated extracellular

free radicals in patients (0.019±0.008, 0.44±0.15, 10.6±6.1), (0.021±0.03,

0.34±0.12, 9.2± 1.3) group1 & group2 respectively as compared with

control (0.011±0.007, 0.33±0.17, 6.8±4.5), while the reverse occurs in the

case of intracellular SOD1 and NO which shows a decrease in T2DM

patients.

Complement components C3, C4 and C- Reactive protein was

estimated and the results was shown positive relationship between FBS

and C3 , C4 concentration also the results show high mean concentration

of C3, C4 & CRP in group1 (142mg/dl, 25.2mg/dl, 6.45mg/dl), group2

(143.3mg/dl, 29.4mg/dl, 5.9mg/dl) as compared with control

(139.3mg/dl, 26.3mg/dl, 4.5mg/dl).

summary

Also blood urea, uric acid and createnin concentrations were

estimated and the results shown high mean concentration of urea

(32.29mg/dl, 30.84mg/dl) in group1, group2 respectively as compared

with control group (26.88mg/dl). And there is apositive correlation

between FBS and blood urea, while there is anegative correlation

between FBS and uric acid, criatenine .

Enzymatic methods were used to determine fasting blood sugar

concentration (FBS), total cholesterol (TC), triglyceride (TG), high

density lipoprotein (HDL), low density lipoprotein (LDL), very low

density lipoprotein (VLDL),and the results shown increased

concentration of TC, TG, LDL, VLDL(208±69.34 , 200.2±69.95,

126±70.93, 40.0±13.99), (168.3±42.7, 189±53.15, 96.1± 53.1, 37.8±

14.5)in group1 & group2 respectively as compared with control(154.4±

37.6 , 141.3±41.8 , 53.1± 40.8 , 28.6± 8.4 ). While HDL concentration

was decreased in patients as compared with control.

Also there was positive correlation between FBS and TC, TG, LDL,

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