abstract

     Metabolic syndrome is a group of metabolic risk factors that exist in one person and it is a serious health condition. People with it have a higher risk of diseases related to fatty buildups in artery walls, coronary heart disease, which can lead to heart attack, is an example. Stroke and peripheral vascular disease are other examples. People with this syndrome are also more likely to develop T2DM.    

     The present study include study some of cardiovascular markers in addition to routine biological variables of lipid profile (triglycerides, total cholesterol, high density lipoprotein – cholesterol and low density lipoproteine – cholesterol) and study their correlation with metabolic syndrome and T2DM. Fasting lipid analysis does not give an accurate picture of pre risk of heart disease therefore become necessary to research at more accurate biological variables as predictors of the incident of cardiovascular risk like hs-C-reactive protein, apolipoprotein-A1 and 25-hydroxyvitamin D.

     This study was conducted at Al-Hussein Medical City / Kerbala /Iraq and   Department of Biochemistry–College of Medicine / University of Kerbala. Samples were randomly selected from the patients attending the diabetic consultation unit at the hospital during Dec,2012 to June, 2013. The patients and control groups were with age ranged between (26 – 65) years .

           The study was carried out on 50 patient with metabolic syndrome (MetS), 40 T2DM patients and their history of the disease have at least two years and 30 apparently healthy subjects as control group.

     The results of the present study show that 25-hydroxyvitamin D was significantly low in serum of metabolic syndrome patients group and T2DM patients compared with control group (P < 0.001) also there was a significant negative correlation with BMI, FBS, TG, hs-CRP and hypertension and it has positive correlation with HDL-C and ApoA1 .

     The results show that TG level , Total cholesterol, LDL-C were significant elevated p<0.001 in MetS compared with normal control group, while serum HDL-cholesterol level was significantly low in MetS patients group as compared with normal control group(P <0.001) BMI, systolic and diastolic blood pressure were significantly high in MetS patients at p<0.001

     The results show significant increase mean value of hs-CRP level in sera of MetS patients compared with normal control group at (p<0.01) and with T2DM which undergo uncontrolled or fluctuation in sugar level at (P < 0.05)

       The results also showed that the mean value of serum apo-A1 was significantly low (P < 0.05) in MetS and T2DM patients compared with normal control group.

       A non-expected result was showed by serum troponin I mean value which were a non-significant change in T2DM and MetS patients compared with normal control group, it dose not show any significant difference between them (P > 0.05).

         The results show significant increase in TG level while Total cholesterol, LDL-C show non-significant elevate p>0.05 in T2DM patients group compared with normal control group, while serum HDL-C level show non-significant decrease p>0.05 compared with normal control group.

               It can be concluded that This show significant decrease in serum levels of Apo A1, HDL-cholesterol with a significant elevation in CRP, TG, LDL-C, Total-