SUMMARY

A study was conducted to evaluate the effect of some biochemical parameters on the heart functions in blood serum of 119 male and female patients of 30 to 59 – years old . compared with 126 healthy persons . groups were divided in to 3 categories according to the age : 1^st categorie was 30 to 39 year old , 2^nd categorie was 40 to 49 year old and 3^rd categorie was 50 to 59 year old for both sex

The enzymatic activity of serum was determind for the following enzymes (Aspartate amino transferase , AST;Alanine amino transferase , ALT; Alkaline phosphatase , ALP; CreatinKinase isoenzyme,CK-MB).

Levels of GSH ; Uric acid ; concentration of Na⁺, K⁺and Ca⁺² were also determined .                                                                                  

Results can be summarized as follow.                                          

* Asignificant increment (p<0.05)in the enzymatic activity of AST,ALT and CK-MB enzymes, Na⁺and K⁺ concentration . on the other hand , asignificant decrease(p<0.05) was found in Ca⁺² con.and GSH in patients of MI

         Asignificant increase in AST,ALP and CK-MB enzymatic activity Na⁺and K⁺con. Of AP patients was optained . A marked decrease(p<0.01) in GSH con. was also noticed . Asignificant increase in AST, CK-MB enzymatic activity was also recorded . whereas , Na⁺and K⁺ con. Was significantly increase (p<0.05)in patients of HF from male of 1^st group.                                        

* patients of second category gave asignificant effect (p<0.05) of enzymatic activity of AST,ALP and CK-MB and Na⁺, K,UA con. For the three patients cases . ALT, enzyme activity of patients of AP and HF within the same category was significantly increase . Ca⁺² con. Was significantly increase in patients of MI but it decreased in patients of HF. GSH con. Was significantly decreased (p<0.05) in all illnes cases.                                          

* Male of the third group revealed a significant increase (p<0.05) in the enzymatic activity of AST and CK-MB of the three illnes cases. The activity of ALT enzyme increase in MI and HF patients . whereas Na⁺, K⁺and Ca⁺²con. increase in those of MI patients . Na and GSH con. Were significantly reduced (p<0.01) in HF patients                                                              

   *   No signs of infection with MI in the females of the 1^st group . this group showed a significant increase (p<0.05) in the enzymatic activity of ALT, ALP, AST and CK-MB and Na⁺ con. With MI and HF patients . mainwhile GSH was decrease in both cases.                                                                                    

* A significant increase (p<0.05) of ALT, AST and CK-MB and Na⁺, UA con.in the 2^nd group . on the other hand ALP and Ca⁺²con. Of MI patients were significantly decreased(p<0.01) in the females of the same group                                

AST and CK-MB activity as well as Na⁺,UA con. Were significantly increased whereas , ALP activity ,Na , UA con. Were significantly increased (p<0.01) in HF patients’ females whereas ALP activity and GSH con. Were markedly decreased (p<0.01) in all three illness cases of the same group .                                          

* Female of the 3^rd group showed asignificant increment (p<0.05)in ALT, ALP, AST and CK-MB activity as well as Na⁺, UA con. Of MI patients. AP patients showed asignificant increase (p<0.05)in CK-MB activity and Na⁺,Ca⁺² and UA con. ALP and ALT activity and GSH con.were significantly decrease . Female of HF patients showed asignificant increase (p<0.01) in CK-MB, ALP, AST activity and UA con. And a significant decrease(p<0.01) in GSH con. Of the same group